Modelling in systems biology - 4PMBMSB4

Objectif(s)

The course provides an introduction to systems biology by focusing on the behaviors emerging from interactions between genes, proteins and RNAs, taking examples from microbes to mammals. The main goal of this course is to show students that abstract computational and mathematical methods can be effectively employed for in silico modeling and analysis of living organisms. Moreover, to enhance practical skills, students will apply some of the techniques and software tools to analyze genome-scale models and models of cell metabolism and gene expression.

Contenu(s)

• Introduction to cellular networks and mathematical modelling (course: 2h)
• Mathematical modelling of cell metabolism: flux balance analysis (course: 2 hours + 2 hours computer lab exercises)
• Kinetic models of integrated networks and introduction to other modelling frameworks (4 hours + 2 hours computer lab exercises)
• Identification and inference of metabolic network models (2 hours + 2 hours computer lab exercises)

No prerequisites